乌药 烏藥 上台乌片 / Wu Yao / Radix Linderae / Lindera Root / Strychndry Chinese herbal

辛，温。

归肺、脾、肾、膀胱经。

行气止痛，温肾散寒。

用于寒凝气滞，胸腹胀痛，气逆喘急，膀胱虚冷，遗尿尿频，疝气疼痛，经寒腹痛。

1、《校注妇人良方》缩泉丸：与益智仁、山药等同用，治肾阳不足、膀胱虚冷之小便频数、小儿遗尿。

2、《医学发明》天台乌药散：治寒疝腹痛，多与小茴香、青皮、高良姜等同用。

3、《和剂局方》小乌沉汤：治胸腹胁肋闷痛，常配香附、甘草等同用。

6～l0g。

气血虚而内热者，虽有气滞，亦当慎用。

Radix Linderae, the dry roots of Lindera aggregata (Sims) Kosterm., is frequently used in traditional Chinese medicine. It contains alkaloids, volatile oils and sesquiterpene esters. In the present study, we investigated the therapeutic potential and underlying mechanisms of the total alkaloids from Radix Linderae (TARL) on collagen II (CII)-induced arthritis (CIA) in mice. TARL (50, 100 and 200mg/kg), orally administered on the same day of an antigen challenge for 20 consecutive days, alleviated disease severity in a dose-dependent manner but did not significantly affect body weights. The TARL treatment reduced the serum level of anti-CII IgG and suppressed the delayed type hypersensitivity evaluated by its effect against CII-induced ear swelling. TARL also protected joint destruction based on the evidence of reducing the histopathological scores. Furthermore, TARL suppressed CII- and concanavalin A-stimulated lymphocyte proliferation in popliteal lymph nodes, where are close to the affected joints in CIA. These data suggest that TARL is a potential therapeutic agent for rheumatoid arthritis that suppresses inflammation and protects joints from destruction.